Many who know me might be shocked by this: I shot my first pistol when I was 8 or 9, taught by my father, a physician, aiming at targets in our basement. At summer camp, I loved riflery the way some kids loved art. Staring through the sight, down the barrel, I proved an excellent shot, gathering ever more advanced medals from the National Rifle Association. As a reward, for my 13th birthday, my uncle gave me a .22 Remington rifle.


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I did not grow up on a farm or in a dangerous place where we needed protection. I grew up in the well-off, leafy suburb of Scarsdale, N.Y.

When I entered high school in the 1970s, I joined the riflery team and often slung my cased gun over my shoulder on my mile-long walk … Read the rest

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The e-bike boom is here. All shapes, sizes, and speeds criss-cross the streets, from middle-schoolers who don’t want to rely on mom and dad for rides around town, to aging athletes who suffer from joint pain, to new parents looking to haul their kids in tow. And that’s just on paved surfaces. Here in Southern California, the e-bike hold has taken strongly enough that it’s almost shocking to now see someone pedaling down the street on an old-school, analog bike. But it’s no surprise; e-bikes are just too damn fun. Recently, we got a chance to test the ultimate e-bike that fills the role of daily driver for all of our parenting needs: Meet the RadWagon 4 from Rad Power Bikes.

Now, I hesitate to call this the “station wagon” of e-bikes. It’s much more sophisticated, cool, and capable than soccer-wagon labels might suggest. My family likes to refer to … Read the rest

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A new research paper posted to the medRxiv* preprint server describes the changes in genomic sequence observed during the course of infection in a patient on the drug tacrolimus, along with steroids, both potent immunosuppressants, and who also received convalescent plasma treatment. These mutations were observed to occur within three weeks from infection.

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If you’ve been stuck mostly at home with one or more family members over the past year, chances are you’ve gotten on one another’s nerves occasionally. When you’re under a lot of stress, it’s not uncommon say something unkind, or even to lash out in anger to someone you care about. And we all make thoughtless mistakes from time to time, like forgetting a promise or breaking something.

Not sure if you should apologize?

Even if you don’t think what you said or did was so bad, or believe that the other person is actually in the wrong, it’s still important to apologize when you’ve hurt or angered someone. “To preserve or re-establish connections with other people, you have to let go of concerns about right and wrong and try instead to understand the other person’s experience,” says Dr. Ronald Siegel, assistant professor of psychology at Harvard Medical School. That … Read the rest

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The CDC and FDA have asked to pause using the Johnson & Johnson COVID-19 vaccine after six women developed a rare blood clot condition and one died. The pause is only expected to last days.

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In early 2013, Hoag Memorial Hospital Presbyterian in Orange County, California, joined with St. Joseph Health, a local Catholic hospital chain, amid enthusiastic promises that their affiliation would broaden access to care and improve the health of residents across the community.


This story also ran on U.S. News & World Report. It can be republished for free.

Eight years later, Hoag says this vision of achieving “population health” is dead, and it wants out. It is embroiled in a legal battle for independence from Providence, a Catholic health system with 51 hospitals across seven states, which absorbed St. Joseph in 2016, bringing Hoag along with it.

In a lawsuit filed in Orange County Superior Court last May, Hoag argues that remaining a “captive affiliate” of the nation’s 10th-largest health system, headquartered nearly 1,200 miles away in Washington state, constrains its ability to meet the needs of the local … Read the rest

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When you’re just starting out surfing, it’s pretty obvious what kind of board you need: A big log of a longboard, ideally with a soft top so you’re less likely to hurt yourself or others. But as you progress and decide to transition to a shortboard, things become far murkier. The wide array of sizes, nose shapes, tail shapes, widths, thicknesses, bottom contours, and fin-box setups make finding the right intermediate surfboard an extremely intimidating process. Believe me, I know.

 

 

Despite having surfed for about 15 years now, I haven’t been able to spend as much time in the water as I’d like, and I’m still very much an intermediate surfer at best. I’ve been riding shortboards for over a decade, but most of them were either a bit too big or a bit too small. This winter I moved back to L.A., and I’ve been getting to surf more … Read the rest

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A new preprint research paper posted to the bioRxiv* server describes the results of a nuclear magnetic resonance (NMR) study to determine the structure of the S protein transmembrane domain (TMD) and its membrane-proximal regions.

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Myasthenia gravis (MG) — a medical term that translates as “serious muscle weakness” — is a rare neuromuscular disease. An estimated 30,000 to 60,000 people in the United States have this disorder, which affects people of all ages, sexes, and ethnicities. Recently updated consensus guidelines have added to our knowledge of different forms of myasthenia gravis and improved approaches to treatment.

What are the symptoms of myasthenia gravis?

Myasthenia gravis impairs the transmission of signals from nerves to muscles at a site called the neuromuscular junction (NMJ), where nerves make contact with muscle. This causes temporary weakness of muscles in use. When the affected muscle or muscle group is rested, it recovers strength.

Throughout the day, your body uses many muscle groups repeatedly; this is true even if you’re not especially active. Because myasthenia gravis is marked by use-related weakness in particular muscle groups, repeated activity of affected muscle makes … Read the rest

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Messaging is important in public health. People who voted for Trump were especially hesitant about a “vaccine passport.” But call it a “verification,” and more people support it.

(Image credit: Nathan Howard/Getty Images)

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